The PRMT2 antibody - N-terminal region (ARP40196_T100) from Aviva Systems Biology is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The PRMT2 antibody - N-terminal region (ARP40196_T100) has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB